Carcinogenicity Tests and Interspecies Concordance

Uncertainties in interspecies extrapolations of carcinogenicity.

The usual classification of results of animal carcinogenicity tests is positive or negative. Attempting to observe correlations between species using such results is complicated by differing test sensitivities. In these circumstances it is helpful to use models to represent the experimental data in a consistent way. Fitting the model parameters to the data allows computation of confidence limit...

Biological Tests for Carcinogenicity

in which ground glass connections could not be used because of the large size of the flasks, it was found that benzene extracts of rubber stoppers previously washed with ether and methanol still contained blue-green fluorescing substances. These extracts had the ultraviolet absorption spectra of carcinogenic hydrocarbons and other compounds of interest. This discovery seemed of such great possi...

Do short-term tests predict rodent carcinogenicity?

Script Concordance Tests: Guidelines for Construction

BACKGROUND SCT is used to assess clinical reasoning in ambiguous or uncertain situations. It allows testing on real-life situations that are not adequately measured with current tests. It probes the multiple judgments that are made in the clinical reasoning process. Scoring reflects the degree of concordance of these judgments to those of a panel of reference experts. METHOD SCT is an item fo...

Predicting carcinogenicity by using batteries of dependent short-term tests.

Among the various methods for predicting carcinogenicity from a battery of short-term tests (STTs), the carcinogenicity prediction and battery selection (CPBS) procedure is the most prominent. A major assumption of CPBS is that the STTs used in the prediction are conditionally independent. Results of recent National Toxicology Program studies of four commonly used in vitro STTs contradict this ...